South Africa has a number of malaria-free safari destinations which are great for a family safari with young children. Madikwe is one of these, a sprawling Big 5 reserve in the North West province on the border of Botswana that is best known as the place where you are most likely to see the endangered African wild dog.
The reserve is easily accessible from Johannesburg with direct light aircraft flights to the Madikwe airstrips. Two hours after departing Joburg you can be sitting with a cocktail gazing over the unique landscape that is punctuated by enormous volcanic intrusions known as inselbergs. From here, your Big 5 safari experience begins.